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Michael Baum, emeritus professor of surgery at University College London, suggested that the sitter had Paget's disease of bone. Paget's may first be noticed as an increasing deformity of a person's bones.
Paget's disease affecting the skull may lead to loss of hearing in one or both ears  due to compression of the nerves in the inner ear.
Rarely, skull involvement may lead to compression of the nerves that supply the eyeleading to vision loss. Advanced Paget's disease may lead to other medical conditions, including: Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. For example, bowing of a femur affected by Paget's may distort overall leg alignment, subjecting the knee to abnormal mechanical forces and accelerating degenerative wear.
Heart failure is a rare, reported consequence of severe Paget's disease i. The abnormal bone formation is associated with recruitment of abnormal blood vessels, forcing the cardiovascular system to work harder pump more blood to ensure adequate circulation.
Nervous system problems may occur in Paget's disease, resulting from increased pressure on the brain, spinal cordor nerves, and reduced blood flow to the brain and spinal cord.
When Paget's disease affects the facial bones, the teeth may become loose. Disturbance in chewing may occur. Chronic dental problems may lead to infection of the jaw bone. Angioid streaks may develop, possibly as a result of calcification of collagen or other pathological deposition.
Vulvar Paget's disease ulceration can occur in female reproductive organs. Although Paget's disease and osteoporosis can occur in the same patient, they are different disorders. Despite their marked differences, several treatments for Paget's disease are also used to treat osteoporosis. Viral[ edit ] Paget's disease may be caused by a slow virus infection i.
Associated viral infections include respiratory syncytial virus canine distemper virus  and the measles virus. Genetic causes may or may not involve a family history of Paget's disease.Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more initiativeblog.com affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation.
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Read about Paget's disease causes, symptoms, statistics, prognosis, diagnosis and treatment. home / arthritis health center / arthritis a-z list / pagets disease center / paget's disease article Paget's Disease of Bone Paget's disease causes no symptoms in a majority of those with the condition and is often incidentally noted when X-ray.
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The things abusers say and do vary, but there is a commonality you can count on: your partner wants to feel powerful and you to feel less than who you are. Key Points. Paget's disease of the nipple is an uncommon type of cancer that forms in or around the nipple and accounts for about 1% of all .